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In addition, while molecular docking provided mechanistic insights, in vitro validation of the proposed SIRT1-mediated pathways was not performed

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Phyre2 analysis of Rha1 predicted high structural homology to CLA-ER, a flavin-dependent enone reductase from Lactococcus plantarum (PDB: 4QLY)(Hou et al, 2015)

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